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COVID-19 pandemic (2019-21) - PLOS Collections

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This Collection of articles highlights all content published across the PLOS journals relating to the COVID-19 pandemic in 2019-21. PLOS is committed to disseminating research as quickly as possible, particularly in public health emergencies. All articles published in any PLOS journal are Open Access free of charge to all readers. Medical Recording Paper

COVID-19 pandemic (2019-21) - PLOS Collections

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Purpose: To evaluate the diagnostic value of symptoms used by daycares and schools to screen children and adolescents for SARS-CoV-2…

To date, there is limited information about the presence of SARS-CoV-2 in semen especially in the acute phase of the infection. While…

Background: We investigated the prevalence of ECG abnormalities and their association with mortality, organ dysfunction and cardiac…

Antimicrobial resistance (AMR) is a global public health crisis that is now impacted by the COVID-19 pandemic. Little is known how…

Introduction: Coronavirus disease 2019 (COVID-19) is the ongoing pandemic with multitude of manifestations and association of ABO blood…

Background: While several parameters have emerged as predictors of prognosis of COVID-19, a simple clinical score at baseline might help…

Background: The COVID-19 pandemic has affected health care systems worldwide. Multidisciplinary teams provide specialist palliative home…

Background and objectives: At present, the focus of the fighting against COVID-19 in China is shifting to strictly prevent the entrance of…

Background: During the early COVID-19 pandemic travel in Uganda was tightly restricted which affected demand for and access to care for…

Identifying order of symptom onset of infectious diseases might aid in differentiating symptomatic infections earlier in a population…

A majority of SARS-CoV-2 infections are transmitted from a minority of infected subjects, some of which may be symptomatic or…

The eligibility of COVID-19 vaccines has been expanded to children aged 12 and above in several countries including Japan, and there is a…

Background: The recommendations in several countries to stop using the ChAdOx1 vaccine has led to vaccine programs combining different…

Background: Gauteng province, with 26.3% of South Africa’s population, is the commercial and industrial powerhouse of the country. During…

Objectives: To exploit the features of digital PCR for implementing SARS-CoV-2 observational studies by reliably including the viral load…

The novel coronavirus SARS-CoV-2, the causative agent of COVID-19 disease, has killed over five million people worldwide as of December…

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the COVID-19 pandemic. Currently, as dangerous mutations…

Background: Among the many collaterals of the COVID-19 pandemic is the disruption of health services and vital clinical research. COVID-19…

Background: Complement activation contributes to lung dysfunction in coronavirus disease 2019 (COVID-19). We assessed whether C5 blockade…

The pandemic spread of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the etiological agent of Coronavirus Disease 2019…

Hypoxemia is a significant driver of mortality and poor clinical outcomes in conditions such as brain injury and cardiac arrest in…

Introduction: The study aimed at exploring the adverse events following immunization (AEFI) and their incidences among health workers in…

Background: Tracheostomy has been proposed as an option to help organize the healthcare system to face the unprecedented number of patients…

Background: Since the COVID-19 pandemic began, there have been concerns related to the preparedness of healthcare workers (HCWs). This…

Background: First reported case of Severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) in Kazakhstan was identified in…

Background: Performance of the SD Biosensor saliva antigen rapid test was evaluated at a large designated testing site in non-hospitalized…

Background: Understanding the actual prevalence of COVID-19 transmission in the community is vital for strategic responses to the pandemic.…

Coronavirus disease 2019 (COVID-19) is currently the biggest public health problem worldwide. Intensive international travel and tourism…

Background and aims: Patients with liver cirrhosis (LC) are considered to be at increased risk for mortality when acquiring SARS-CoV-2…

Background: Tuberculosis (TB) and COVID-19 pandemics are both diseases of public health threat globally. Both diseases are caused by…

Introduction: Colchicine may inhibit inflammasome signaling and reduce proinflammatory cytokines, a purported mechanism of COVID-19…

The objective of this retrospective cohort study was to describe pre-treatment characteristics, treatment patterns, health resource use,…

Background: Risk factors for the development of severe COVID-19 disease and death have been widely reported across several studies.…

Introduction: The COVID-19 pandemic has affected the health systems in many ways. It has put unprecedented strain on health systems…

Objective: To identify predicators of patients with fibromyalgia (FM) that are associated with a severe COVID-19 disease course. Methods:…

Introduction: Ankle fractures have continued to occur through the COVID pandemic and, regardless of patient COVID status, often need…

Given the overwhelming worldwide rate of infection and the disappointing pace of vaccination, addressing reinfection is critical.…

Background: COVID-19 caused by SARS-CoV-2 ranges from asymptomatic to severe disease and can cause fatal and devastating outcome in many…

Although patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), influenza A, influenza B and respiratory…

Introduction: COVID-19 infection has been hypothesized to precipitate venous and arterial clotting events more frequently than other…

Introduction: Delay between symptom onset and access to care is essential to prevent clinical worsening for different infectious diseases.…

Aims: Patients with cardiovascular comorbidities have a significantly increased risk for a critical course of COVID-19. As the SARS-CoV2…

Introduction: This study was performed to determine the clinical outcomes of patients with mild symptoms of COVID-19 discharged from the…

Background: Studies of outpatients with mild or moderate COVID-19 are uncommon. We studied: 1) association of symptoms with reverse…

Background: Risk factors of severe COVID-19 have mainly been investigated in the hospital setting. We investigated pre-defined risk factors…

Objective: The proportion of COVID-19 patients having active pulmonary tuberculosis, and its impact on COVID-19 related patient outcomes,…

Objectives: Older adults are particularly vulnerable to the negative consequences of antipsychotic exposure and are disproportionally…

Background: Coronavirus disease 2019 (COVID-19) has affected millions of lives globally. However, the disease has presented more extreme…

Background: The aim of this study was to describe the clinical characteristics and outcome of patients with coronavirus disease-2019…

Non-specific protective effects of certain vaccines have been reported, and long-term boosting of innate immunity, termed trained…

Objectives: Remdesivir is one of the most widely recommended and used medications for COVID-19 treatment. However, different outcomes have…

The objective was to describe the clinical characteristics and outcomes of hospitalized COVID-19 patients during the two different…

Effective, low-cost therapeutics are needed to prevent and treat COVID-19. Severe COVID-19 disease is linked to excessive inflammation.…

Background: Elevated D-dimer is known as predictor for severity of SARS-CoV2-infection. Increased D-dimer is associated with thromboembolic…

Background: Patients with COVID-19 present with a variety of clinical manifestations, ranging from mild or asymptomatic disease to severe…

Introduction: Coronavirus disease (Covid-19) has led to a global pandemic since its emergence in December 2019. The majority of research…

Background: Previous studies have assessed the prevalence and characteristics of self-medication in COVID-19. However, no systematic review…

Introduction: Neoadjuvant chemotherapy has become standard of care for cisplatin-eligible patients with muscle-invasive bladder cancer…

Introduction: Famotidine is a competitive histamine H2-receptor antagonist most commonly used for gastric acid suppression but thought to…

Background: Acute kidney injury (AKI) is associated with poor outcomes in COVID patients. Differences between hospital-acquired (HA-AKI)…

Background: The efficacy of the BioNTech-Pfizer BNT162b2 vaccination in the elderly (≥80 years) could not be fully assessed in the…

Objectives: To investigate nurses’ behavioral intention toward caring for COVID-19 patients on mechanical ventilation, as well as the…

Protecting healthcare professionals is crucial in maintaining a functioning healthcare system. The risk of infection and optimal…

Background: The transmission dynamics of SARS-CoV-2 varies depending on social distancing measures, circulating SARS-CoV-2 variants, host…

Two mRNA vaccines (BNT162b2 and mRNA-1273) against severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) are globally authorized as…

Olfactory loss has been identified as one of the common symptoms related to COVID-19 infection. Although olfactory loss is recognized, our…

Objectives: Fatigue syndromes have been widely observed following post-viral infection and are being recognised because of Covid19.…

Background: The COVID-19 pandemic seems to have a different picture in Africa; the first case was identified in the continent after it had…

Background: People at high risk of severe illness from COVID-19 have experienced greater restrictions during the pandemic, yet there is a…

Introduction: The incidence of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infections in the Belgian community is mainly…

Background: Clinical observations have shown that there is a relationship between coronavirus disease 2019 (COVID-19) and atypical…

Background: Clinical outcomes among COVID-19 patients vary greatly with age and underlying comorbidities. We aimed to determine the…

Background: A large portion of COVID-19 cases and deaths in the United States have occurred in nursing homes; however, current literature…

Objective: To compare hospitalized reproductive age women with COVID-19 who were pregnant, puerperal, or neither one nor the other in terms…

Coronavirus Disease 2019 (COVID-19), during the second wave in early 2021, has caused devastating chaos in India. As daily infection rates…

Several studies of patients with COVID-19 have evaluated biological markers for predicting outcomes, most of them retrospectively and with…

Background: Coronavirus disease 19 (COVID-19) is a newly emerging pandemic affecting more than 120 million people globally. Compliance with…

Introduction: Cases of the novel coronavirus disease (COVID-19) continue to spread around the world even one year after the declaration of…

Introduction: Coronavirus disease 2019 (COVID-19) has affected millions of people worldwide, and several sociodemographic variables,…

SARS-CoV-2 pandemic has greatly affected healthcare workers because of the high risk of getting infected. The present cross-sectional…

Last year observed a global pandemic caused by SARS-CoV-2 (severe acute respiratory syndrome-coronavirus 2) infection affecting millions…

Introduction: The coronavirus disease (COVID-19) pandemic has caused unprecedented challenges for the medical staff worldwide, especially…

The COVID-19 pandemic continues to impact people worldwide–steadily depleting scarce resources in healthcare. Medical Artificial…

Background: During the COVID-19 pandemic, telehealth technologies were used in the primary health care setting in New Brunswick as a means…

Background: Somalia is considered severely underprepared to contain an outbreak of COVID-19, with critical shortages in healthcare…

Background/Introduction: Psychological and physical well-being of health personnel has been significantly affected by COVID-19. Work…

Therapeutic drug monitoring (TDM) is essential for voriconazole to ensure optimal drug exposure, mainly in critically ill patients for…

Introduction: Mildly symptomatic cases of Covid-19 in previously-well individuals form the majority of infections and also serve as potent…

Drug repurposing has the potential to bring existing de-risked drugs for effective intervention in an ongoing pandemic—COVID-19 that has…

Background: Long-COVID refers to a variety of symptoms affecting different organs reported by people following Coronavirus Disease 2019…

Objectives: Most COVID-19 related infections and deaths may occur in healthcare outside hospitals. Here we explored SARS-CoV-2 infections…

Introduction: The novel coronavirus pandemic (COVID–19) represents a major public health problem and it is key to find a treatment that…

Objectives: Studies have shown that acute kidney injury (AKI) occurrence post SARS-CoV-2 infection is complex and has a poor prognosis.…

Background: The COVID-19 pandemic has had a devastating impact on healthcare systems and care delivery, changing the context for patient…

Background: During the COVID-19 pandemic, telehealth became a vital resource to contain the virus’s spread and ensure continuity of care of…

Background: Data of critically ill COVID-19 patients are being evaluated worldwide, not only to understand the various aspects of the…

Objective: To analyze the geographical variation in the provision of health services, namely in demand, patterns of utilization, and…

Background: While many studies have reported the rate and risk of SARS-CoV-2 infection among healthcare workers (HCWs), there are scant…

Objective: To determine whether severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is present in the vagina of women diagnosed…

Background: Few studies have quantified aerosol concentrations of SARS-CoV-2 in hospitals and long-term care homes, and fewer still have…

Background: The COVID-19 pandemic has sparked a surge in the use of virtual communication tools for delivering clinical services for many…

Background: The first Covid-19 epidemic outbreak has enormously impacted the delivery of clinical healthcare and hospital management…

Background: All healthcare workers (HCWs) in Yongin Severance Hospital were allocated to receive the ChAdOx1 nCov-19 vaccine according to…

Background: Given the rapid increased in confirmed coronavirus disease 2019 (COVID-19) and related mortality, it is important to identify…

Background/Aims: We measured the association between underlying chronic hepatitis B (CHB) and antiviral use with infection rates among…

Introduction: Several studies have described typical clinical manifestations, including fever, cough, diarrhea, and fatigue with COVID-19…

Introduction: COVID-19 is a pandemic respiratory disease caused by the highly contagious novel coronavirus (SARS-CoV 2). The disease is now…

Objective: Data on the course of severe COVID-19 in inflammatory bowel disease (IBD) patients remains limited. We aimed to determine the…

Patients after lung transplantation are at risk for life-threatening infections. Recently, several publications on COVID-19 outcomes in…

Background: Understanding risk factors for short- and long-term COVID-19 outcomes have implications for current guidelines and practice. We…

We collected a multi-centric retrospective dataset of patients (N = 213) who were admitted to ten hospitals in Czech Republic and tested…

Background: In March 2020, an influx of admissions in COVID-19 positive patients threatened to overwhelm healthcare facilities in East…

Background: Clinical features and outcomes of SARS-CoV-2 infections diverge in different countries. The aim of this study was to describe…

Background: Telemedicine has been rapidly adopted in the wake of the COVID-19 pandemic. There is limited work surrounding demographic and…

Aim: To explore the temporal impact of mild COVID-19 on need for primary and specialist health care services. Methods: In all adults (≥20…

This study aimed to assess the prevalence of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) total antibodies in the north,…

Background: Coronavirus disease (COVID-19) is associated with a high mortality rate in older adults; therefore, it is important for medical…

Introduction: Since their emergence, SARS-CoV-2 variants of concern (VOC) B.1.1.7 and B.1.351 have spread worldwide. We estimated the risk…

Background: Nosocomial spread of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has been widely reported, but the…

Millions of Americans have been infected with COVID-19 and communities of color have been disproportionately burdened. We investigated the…

The purpose of this study was to clarify the effects of individual infection control measures and physical distancing on pediatric medical…

Background: J-waves represent a common finding in routine ECGs (5–6%) and are closely linked to ventricular tachycardias. While arrhythmias…

Objective: This cross-sectional observational study summarized the baseline characteristics of subjects who underwent COVID-19 molecular…

Background: The relationship between statin treatment and Coronavirus Disease 2019 (COVID-19) mortality has been discussed due to the…

Background: Coronavirus Disease 2019 (COVID-19) is a respiratory viral illness causing pneumonia and systemic disease. Abnormalities in…

Background and objective: The risk factors for breakthrough infections among healthcare workers (HCW) after completion of a full course of…

Continuous positive airway pressure (CPAP) has been successfully applied to patients with COVID-19 to prevent endotracheal intubation.…

Understanding and monitoring the epidemiological time delay dynamics of SARS-CoV-2 infection provides insights that are key to discerning…

Background: Qualitative olfactory (smell) dysfunctions are a common side effect of post-viral illness and known to impact quality of life…

Objectives: We conducted the present multicenter, retrospective study to assess the epidemiological, clinical, laboratory, and radiological…

Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) seroprevalence studies bridge the gap left from case detection, to…

Background: Patients with COVID-19 are follow-up in primary care and long COVID is scarcely defined. The study aim was to describe…

Background: The burden of the COVID-19 pandemic in Peru has led to people seeking alternative treatments as preventives and treatment…

Introduction: The COVID-19 pandemic continues to overwhelm health systems across the globe. We aimed to assess the readiness of hospitals…

Background: Background Population-based data on SARS-CoV-2 infection in pregnancy and assessment of passive immunity to the neonate, is…

Ensuring the safety of healthcare workers is vital to overcome the ongoing COVID-19 pandemic. We here present an analysis of the social…

The COVID-19 pandemic has dramatically impacted cancer care worldwide. Disruptions have been seen across all facets of care. While the…

Background: Myocardial infarction (MI) is the most prevalent cardiovascular disease globally and is considered a public health problem. In…

Introduction: Coronavirus disease-19 (COVID-19), which started in late December, 2019, has spread to affect 216 countries and territories…

Background: The Covid-19 pandemic has caused significant morbidity and mortality among patients with cancer. Most countries employed…

Background: The COVID-19 pandemic has had a devastating impact in the United States, particularly for Black populations, and has heavily…

Prior studies have demonstrated that immunologic dysfunction underpins severe illness in COVID-19 patients, but have lacked an in-depth…

Purpose: The outbreak of coronavirus disease 2019 (COVID-19) has caused many children to stay indoors. Increased near work and insufficient…

Introduction: During COVID-19 pandemic, the use of several drugs has represented the worldwide clinical practice. However, though the…

Background: Epidemiological features characterization of COVID-19 is highly important for developing and implementing effective control…

It has been widely observed that adult men of all ages are at higher risk of developing serious complications from COVID-19 when compared…

SARS-CoV-2 affects mainly the lungs, however, other manifestations, including neurological manifestations, have also been described during…

Objective: To evaluate the effectiveness of Tocilizumab (with or without corticosteroids) in a real-life context among moderate-to-severe…

Background: The onset of the COVID-19 pandemic was characterized by rapid increases in Emergency department (ED) patient visits. EDs…

Background: Due to the many restrictions imposed during the COVID-19 emergency, the normal clinical activities have been stopped abruptly…

Background: There is an urgent need for novel therapeutic strategies for reversing COVID-19-related lung inflammation. Recent evidence has…

Background: The objective of this cohort study was to determine whether elevated CRP in early COVID-19 was associated with 14-day mortality…

Background: People with good health knowledge present a conceptual and objective appropriation of general and specific health topics,…

The pandemic of Coronavirus disease 2019 (COVID-19) has brought significant pressure on nurses globally as they are the frontline of care.…

Background: Most current evidence on risk factors for hospitalization because of coronavirus disease 2019 (COVID-19) comes from studies…

Objectives: To study abnormality of spirometry, six-minute walk distance, and chest radiograph among patients recovered from Coronavirus…

Background: The COVID-19 pandemic has presented emergency medical services (EMS) worldwide with the difficult task of identifying patients…

Introduction: Coronavirus disease (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2. Although most patients with…

Background: COVID-19 has proved to have an indirect impact on essential health services in several parts of the world which could lead to…

Introduction: Coronavirus disease 2019 (COVID-19) has emerged as a global pandemic since its outbreak in Wuhan, China. It is an urgent task…

Background: Patients with hepatocellular carcinoma (HCC) represent a vulnerable population potentially negatively affected by…

Introduction: Coronavirus Disease 2019 is a primarily respiratory illness that can cause thrombotic disorders. Elevation of D-dimer is a…

Coronavirus disease (COVID)-19, as a result of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection, has been the direct…

Long-COVID-19 is a proposed syndrome negatively affecting the health of COVID-19 patients. We present data on self-rated health three to…

Scientific evidence plays an important role in the therapeutic decision-making process. What happens when physicians are forced to make…

Purpose: This cross-sectional observational study aims to report preliminary data from the first experience using tocilizumab for patients…

Purpose: To investigate the impact on services for rhegmatogenous retinal detachment (RRD) patients during the COVID-19 (2019coronal virus…

Background: Cardiac injury associated with cytokine release frequently occurs in SARS-CoV-2 mediated coronavirus disease (COVID19) and…

With more than 82 million cases worldwide and almost two million deaths, the Covid-19 global pandemic shows little sign of abating.…

Background: Microbial keratitis (MK) is the most common non-surgical ophthalmic emergency, and can rapidly progress, causing irreversible…

Background: Chloroquine was promoted as a COVID-19 therapeutic early in the pandemic. Most countries have since discontinued the use of…

Background: Obesity has emerged as a risk factor for severe coronavirus disease 2019 (COVID-19) infection. To inform treatment…

Introduction: The coronavirus disease (COVID-19) pandemic has delayed the management of other serious medical conditions. This study…

COVID-19 pandemic (2019-21) - PLOS Collections

Ecg Roll Paper Prize Background: Mexico is one of the countries with the highest number of deaths from the COVID-19 pandemic. In spite of this high mortality,…